What initial treatment is recommended for an acute gout flare?

The recommended initial treatment for an acute gout flare is the use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as Indomethacin or Naproxen Sodium. These medications work effectively to reduce inflammation and pain associated with gout attacks by inhibiting the synthesis of prostaglandins, which are mediators of inflammation.

NSAIDs are commonly chosen due to their rapid onset of action and their ability to provide symptom relief. They can be particularly beneficial in the early stages of a gout flare when inflammation is at its peak. The selection of specific NSAIDs may vary based on patient tolerance, contraindications, and other individual health considerations, but they remain a cornerstone treatment for acute gout.

While colchicine is also a valid option in the treatment of gout flare, it is not the first-line treatment when NSAIDs are available and tolerated, as they tend to work faster for relieving pain and inflammation. Lifestyle changes and corticosteroids, while they can play a role in the overall management of gout, are not typically initiated as exclusive treatments for acute flares. Lifestyle adjustments may complement pharmacologic treatments but do not address the acute symptoms directly. Corticosteroids can be used when NSAIDs are contraindicated, but they are not the first choice in