What is a significant risk associated with the use of fluoroquinolones?

The use of fluoroquinolones is significantly associated with an increased risk of Achilles tendon rupture. This class of antibiotics has been linked to tendon damage, particularly in weight-bearing joints, and the Achilles tendon is especially vulnerable. The risk is heightened in older adults, those who are concurrently taking corticosteroids, and individuals engaging in strenuous physical activities. This side effect makes it essential for healthcare providers to carefully assess the need for fluoroquinolones in patients, particularly in those who may have additional risk factors for tendon injury. Monitoring for symptoms such as pain, swelling, or stiffness in the Achilles tendon is also crucial once a patient is prescribed these medications.