What is the primary concern when prescribing new medications for older adults?

When prescribing new medications for older adults, the primary concern is the potential for drug-drug interactions. As individuals age, they are more likely to have multiple health conditions, often requiring various medications concurrently. This polypharmacy can significantly increase the risk of adverse drug interactions, which may lead to serious complications, hospitalizations, or exacerbation of existing conditions.

Older adults may also have altered pharmacokinetics and pharmacodynamics due to changes in metabolism, organ function, and body composition as they age. This further complicates medication management and heightens the importance of carefully considering how new medications may interact with those already being taken. It is essential for healthcare providers to conduct thorough medication reconciliation and to monitor patients closely when introducing new therapies.

While cost, patient preference, and availability are important considerations in prescribing, they do not hold the same immediate significance as the risk of drug interactions, which can directly impact the safety and health outcomes of older adults. Promoting medication safety and optimizing therapeutic regimens are paramount in geriatric care.